Asymmetric addition of α-branched cyclic ketones to allenamides catalyzed by a chiral phosphoric acid† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c5sc04202j Click here for additional data file.

A new approach to the asymmetric Mannich reaction catalyzed by chiral N,N′-dioxide–metal complexes† †Electronic supplementary information (ESI) available. CCDC 1448521 and 1480808.For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c6sc03902b Click here for additional data file. Click here for additional data file.

Enantioselective [2 + 2] cycloaddition of N-allenamides with cyclic N-sulfonylketimines: access to polysubstituted azetidines bearing quaternary stereocenters† †Electronic supplementary information (ESI) available: Experimental procedure, characterization data for all the new compounds, and chiral HPLC spectra for the products. CCDC 1495550. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c6sc05450a Click here for additional data file. Click here for additional data file.

A Ni(ClO4)2-catalyzed enantioselective [2 + 2] cycloaddition ofN-allenamides with cyclicN-sulfonylketimines was developed, which regioselectively occurred at the proximal C]C bonds of the N-allenamides. Broad substrate scope of N-allenamides and cyclic N-sulfonylketimines was observed. A range of fused polysubstituted azetidines bearing quaternary stereocenters were afforded in good yields and ...

Enantioselective α-amination enabled by a BINAM-derived phase-transfer catalyst† †Electronic supplementary information (ESI) available: Procedures and characterization data. CCDC 1025135. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c4sc02494j Click here for additional data file. Click here for additional data file.

Chiral anion phase-transfer of aryldiazonium cations was utilized to achieve highly enantioselective α-amination of carbonyl compounds. A broad scope of indanone- and benzosuberone-derived substrates was amenable to this strategy. Critical to obtaining high levels of enantioselectivity was the use of BINAM-derived phosphoric acids. The utility of this transformation was demonstrated through fac...

Palladium(0)-catalyzed asymmetric C(sp3)–H arylation using a chiral binol-derived phosphate and an achiral ligand† †Electronic supplementary information (ESI) available: Full optimization tables, procedural, spectral and X-ray crystallographic (CIF) data, and DFT calculations. CCDC 1486752 and 1486753. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c6sc04006c Click here for additional data file. Click here for additional data file.

The first efficient palladium(0)-catalyzed enantioselective C(sp)–H activation reaction using a catalytic chiral base and an achiral phosphine ligand is reported. Fine-tuning the binol-derived phosphoric acid pre-catalyst and the reaction conditions was found to be crucial to achieve high levels of enantioselectivity for a variety of indoline products containing both triand tetrasubstituted ste...

Gold(i)-catalyzed [2 + 2 + 2] cycloaddition of allenamides, alkenes and aldehydes: a straightforward approach to tetrahydropyrans† †Electronic supplementary information (ESI) available: Characterization data and experimental procedures. CCDC 1038447–1038449. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c5sc00295h Click here for additional data file. Click here for additional data file.

Centro Singular de Investigación en Qúım (CIQUS) and Departamento de Qúımica Compostela, C/ Jenaro de la Fuente s/n, E-mail: [email protected]; fernan Instituto de Qúımica Orgánica General (CS Spain † Electronic supplementary information and experimental procedures. CCDC crystallographic data in CIF or o 10.1039/c5sc00295h ‡ HF and IV equally contributed to this w Cite this: Chem. Sci....